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Drug Discov Today. 2002 May 15;7(10):569-79.

Hydrogels: from controlled release to pH-responsive drug delivery.

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  • 1National Institute of Pharmaceutical, Education and Research, Sector 67, S.A.S. Nagar, Punjab 160 062, India.


Hydrogels are one of the upcoming classes of polymer-based controlled-release drug delivery systems. Besides exhibiting swelling-controlled drug release, hydrogels also show stimuli-responsive changes in their structural network and hence, the drug release. Because of large variations in physiological pH at various body sites in normal as well as pathological conditions, pH-responsive polymeric networks have been extensively studied. This review highlights the use of hydrogels (a class of polymeric systems) in controlled drug delivery, and their application in stimuli-responsive, especially pH-responsive, drug release.

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