University of Wisconsin Medical School, Sinai Samaritan Medical Center, Milwaukee, WI 53233, USA. nvakil@facstaff.wisc.edu
Recent data on gastro-oesophageal reflux disease management strategies suggest that the indirect costs of reflux disease are high, and that inadequate treatment is associated with significant out-patient costs for patients. Long-term management strategies now focus on discontinuous therapy for some subgroups of patients. On-demand therapy is particularly attractive for patients who have no mucosal disease.