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Nat Rev Genet. 2002 Jun;3(6):462-73.

Redefining bacterial populations: a post-genomic reformation.

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  • 1Department of Microbiology and Immunology, Stanford University School of Medicine, 299 Campus Drive, Fairchild D 037, Stanford, California 94305-5402, USA. ejoyce@stanford.edu


Sexual reproduction and recombination are essential for the survival of most eukaryotic populations. Until recently, the impact of these processes on the structure of bacterial populations has been largely overlooked. The advent of large-scale whole-genome sequencing and the concomitant development of molecular tools, such as microarray technology, facilitate the sensitive detection of recombination events in bacteria. These techniques are revealing that bacterial populations are comprised of isolates that show a surprisingly wide spectrum of genetic diversity at the DNA level. Our new awareness of this genetic diversity is increasing our understanding of population structures and of how these affect host pathogen relationships.

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