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    Clin Biochem. 1975 Dec;8(6):353-64.

    Individual variation in inosine triphosphate accumulation in human erythrocytes.

    Fraser JH, Meyers H, Henderson JF, Brox LW, McCoy EE.

    Abstract

    Erythrocytes from 5% of a normal population accumulated relatively high amounts of radioactive inosine triphosphate (i.e., greater than 70 nmoles/10(10) cells in 2 hr) when they were incubated with [14C]hypoxanthine. The incidence of this characteristic in a mentally retarded population was 16%. Inosine triphosphate was synthesized from [14C]hypoxanthine, but not from [14C]adenine or [14C]guanine. The metabolism of [14C]adenine and [14C]guanine was the same in erythrocytes that accumulated "normal" and "high" amounts of inosine triphosphate. Inosine triphosphate did not accumulate in leukocytes.

    PMID:
    1204209
    [PubMed - indexed for MEDLINE]

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