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Am J Clin Oncol. 2002 Jun;25(3):274-6.

Metastatic dedifferentiated chordoma with elevated beta-hCG: a case report.

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  • 1Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor 48109-0948, USA.


Chordomas are relatively uncommon bone tumors, and fewer than 10% of cases are classified as dedifferentiated chordomas. These tumors tend to be more clinically aggressive than chordomas and have a higher incidence of early distant metastases. In this case report, we describe a 24-year-old man with dedifferentiated chordoma and multiple pulmonary metastases. Further laboratory analysis revealed an elevated serum beta-human chorionic gonadotropin level. Unfortunately, the patient's clinical condition deteriorated rapidly and he died before receiving any treatment for his cancer. However, chemotherapy may play a useful role in the management of systemic disease in patients with dedifferentiated chordoma.

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