Synthesis of novel furo, thieno, and benzazetoazepines and evaluation of their cytotoxicity

Bioorg Med Chem Lett. 2002 Jun 17;12(12):1675-7. doi: 10.1016/s0960-894x(02)00232-9.

Abstract

We report the regio- and stereoselective synthesis of a novel cis-C(3)N-C(4)X-C(6)N series (X=O, S, and C(2)) from cyclic ketones. The cytotoxic activity of the new compounds was studied in five cell lines; the observed activities were in accordance with the concept of bioisosteric replacement.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology*
  • Azepines / chemical synthesis*
  • Azepines / pharmacology*
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Azepines