Br J Radiol. 2002 May;75(893):460-3.

Heterotopic calcification as a late radiation effect: report of 15 cases.

Source

Department of Radiation Oncology, Diakoniekrankenhaus Rotenburg, Postfach 1211, D-27342 Rotenburg, Germany.

Abstract

The LENT-SOMA scoring system for reporting late tissue effects following therapeutic radiation does not include heterotopic calcification as an end-point. Here we report on 15 long-term radiotherapy survivors with significant heterotopic calcifications. In all cases heterotopic calcification was linked to other radiation sequelae, e.g. ulceration, bone necrosis, nerve damage and fibrosis. The median time interval between radiotherapy and the occurrence of heterotopic calcification was 19 years (range 2-31 years). All patients received doses in excess of 40 Gy; overlap of adjacent fields played a role in some cases. It appears that heterotopic calcification can be regarded as end-stage damage following high dose radiotherapy. Heterotopic calcification in conjunction with local tissue breakdown is highly suggestive of previous radiation treatment.

PMID:: 12036841; [PubMed - indexed for MEDLINE]

Free full text

MeSH Terms

LinkOut - more resources

Full Text Sources

Medical

Cancer - MedlinePlus Health Information

Supplemental Content

Related citations

Partial breast irradiation with interstitial 60CO brachytherapy results in frequent grade 3 or 4 toxicity. Evidence based on a 12-year follow-up of 70 patients. [Int J Radiat Oncol Biol Phys. 2004]
Partial breast irradiation with interstitial 60CO brachytherapy results in frequent grade 3 or 4 toxicity. Evidence based on a 12-year follow-up of 70 patients.
Póti Z, Nemeskéri C, Fekésházy A, Sáfrány G, Bajzik G, Nagy ZP, Bidlek M, Sinkovics I, Udvarhelyi N, Liszkay G, et al. Int J Radiat Oncol Biol Phys. 2004 Mar 15; 58(4):1022-33.
Long-term radiation sequelae after breast-conserving therapy in women with early-stage breast cancer: an observational study using the LENT-SOMA scoring system. [Int J Radiat Oncol Biol Phys. 2003]
Long-term radiation sequelae after breast-conserving therapy in women with early-stage breast cancer: an observational study using the LENT-SOMA scoring system.
Fehlauer F, Tribius S, Höller U, Rades D, Kuhlmey A, Bajrovic A, Alberti W. Int J Radiat Oncol Biol Phys. 2003 Mar 1; 55(3):651-8.
Increasing the rate of late toxicity by changing the score? A comparison of RTOG/EORTC and LENT/SOMA scores. [Int J Radiat Oncol Biol Phys. 2003]
Increasing the rate of late toxicity by changing the score? A comparison of RTOG/EORTC and LENT/SOMA scores.
Hoeller U, Tribius S, Kuhlmey A, Grader K, Fehlauer F, Alberti W. Int J Radiat Oncol Biol Phys. 2003 Mar 15; 55(4):1013-8.
Review Radiation therapy in the multimodal treatment approach of pituitary adenoma. [Strahlenther Onkol. 2002]
Review Radiation therapy in the multimodal treatment approach of pituitary adenoma.
Becker G, Kocher M, Kortmann RD, Paulsen F, Jeremic B, Müller RP, Bamberg M. Strahlenther Onkol. 2002 Apr; 178(4):173-86.
Review Current and future strategies in radiotherapy of childhood low-grade glioma of the brain. Part II: Treatment-related late toxicity. [Strahlenther Onkol. 2003]
Review Current and future strategies in radiotherapy of childhood low-grade glioma of the brain. Part II: Treatment-related late toxicity.
Kortmann RD, Timmermann B, Taylor RE, Scarzello G, Plasswilm L, Paulsen F, Jeremic B, Gnekow AK, Dieckmann K, Kay S, et al. Strahlenther Onkol. 2003 Sep; 179(9):585-97.

See reviews... See all...

Cited by 1 PubMed Central article

Review Animal models of typical heterotopic ossification. [J Biomed Biotechnol. 2011]
Review Animal models of typical heterotopic ossification.
Kan L, Kessler JA. J Biomed Biotechnol. 2011; 2011:309287. Epub 2010 Oct 19.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Heterotopic calcification as a late radiation effect: report of 15 cases.
Heterotopic calcification as a late radiation effect: report of 15 cases.
Br J Radiol. 2002 May ;75(893):460-3.

PubMed
The limited role of midnight salivary cortisol levels in the diagnosis of subcli...
The limited role of midnight salivary cortisol levels in the diagnosis of subclinical hypercortisolism in patients with adrenal incidentaloma.
Eur J Endocrinol. 2009 Jan ;160(1):87-92. Epub 2008 Oct 3 .

PubMed
Estimating intrapartum-related perinatal mortality rates for booked home births:...
Estimating intrapartum-related perinatal mortality rates for booked home births: when the 'best' available data are not good enough.
BJOG. 2009 Jun ;116(7):933-42.

PubMed
Parallel determination of phenotypic cytotoxicity with a micropattern of mutant ...
Parallel determination of phenotypic cytotoxicity with a micropattern of mutant cell lines.
Biomed Microdevices. 2009 Apr ;11(2):443-52.

PubMed
Detection of the rapid emergence of the H275Y mutation associated with oseltamiv...
Detection of the rapid emergence of the H275Y mutation associated with oseltamivir resistance in severe pandemic influenza virus A/H1N1 09 infections.
Antiviral Res. 2010 Jul ;87(1):16-21. Epub 2010 Apr 10 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Heterotopic calcification as a late radiation effect: report of 15 cases.

Source

Abstract

MeSH Terms

MeSH Terms

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Related citations

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information