Send to

Choose Destination
See comment in PubMed Commons below
J Med Chem. 2002 Jun 6;45(12):2417-24.

Discovery of potent, nonsteroidal, and highly selective glucocorticoid receptor antagonists.

Author information

  • 1Pfizer Global Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06371, USA.


An approach to the computer-assisted, pharmacophore design of nonsteroidal templates for the glucocorticoid receptor (GR) that contained an element of pseudo-C2 symmetry was developed. The enatiomer of the initial design, 1Ra, and not the designed molecule, 1S, showed the desired ligand binding to the GR. The pseudo-C2 symmetry of the template allowed for rapid improvements in GR activity resulting in potent, selective, nonsteroidal GR antagonists, CP-394531 and CP-409069.

[PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Chemical Information


PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Write to the Help Desk