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Biometrics. 1975 Dec;31(4):949-52.

The analysis of binary responses from toxicological experiments involving reproduction and teratogenicity.


This paper describes a parametric method for analyzing binary response data from completely randomized experiments in which the experimental units are animal litters. Responses within a litter are assumed to form a set of Bernoulli trials whose success probability varies between litters in the same treatment group according to a two parameter beta distribution. The parameters of the beta distribution for each treatment are estimated by maximum likelihood and treatment differences are tested by asymptotic likelihood ratio tests.

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