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    Diabetes. 2002 Jun;51(6):1986-8.

    Insertion/deletion polymorphism of the ACE gene is associated with type 2 diabetes.

    Feng Y, Niu T, Xu X, Chen C, Li Q, Qian R, Wang G, Xu X.

    Division of Endocrinology, the Third Affiliated Hospital of Beijing University, Beijing, China.

    In an attempt to examine the role of an ACE gene insertion/deletion (I/D) polymorphism in type 2 diabetes, we conducted a case-control association study among 132 couple-pairs from northern China. The genotype frequencies for II, ID, and DD were 39.8, 39.8, and 20.3%, respectively, in the case group and 44.8, 44.8, and 10.4% in the control group. The DD frequency was significantly higher in the case group than in the control group (chi(2)(1) = 4.77, P = 0.03), suggesting that the DD genotype is associated with an increased susceptibility to type 2 diabetes in our study population.

    PMID: 12031990 [PubMed - indexed for MEDLINE]

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