Department of Chemistry, Celltech R&D Inc., 1631 220th Street SE, Bothell, WA 98021, USA. ncutshall@ceptyr.com
A series of 4-fluoronicotinanilides was synthesized and shown to be novel, potent, and selective inhibitors against GRO-alpha-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, autoimmune, and allergic disorders.