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1: Bioorg Med Chem Lett. 2002 Jun 3;12(11):1517-20.Click here to read Links

Nicotinanilides as inhibitors of neutrophil chemotaxis.

Cutshall NS, Kucera KA, Ursino R, Latham J, Ihle NC.

Department of Chemistry, Celltech R&D Inc., 1631 220th Street SE, Bothell, WA 98021, USA. ncutshall@ceptyr.com

A series of 4-fluoronicotinanilides was synthesized and shown to be novel, potent, and selective inhibitors against GRO-alpha-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, autoimmune, and allergic disorders.

PMID: 12031332 [PubMed - indexed for MEDLINE]