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J Endocrinol Invest. 2002 Apr;25(4):369-72.

Ectopic ACTH syndrome associated with ovarian steroid-cell tumor.

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  • 1Department of Internal Medicine, Endocrinology and Hemostatic Disorders, Medical University of Gdansk, Poland.


Several cases of ovarian neoplasms resulting in Cushing's syndrome due to ectopic secretion of ACTH or ectopic secretion of F have been reported. Tumors producing ACTH include adenocarcinoma, androblastoma, Sertoli cell carcinoma, carcinoid tumor and teratoma. Cortisol secretion has been reported in ovarian steroid cell tumor (unclassified steroid cell tumor). We present a case of a 19-year-old woman with Cushing's syndrome in course of an ovarian steroid cell tumor with ectopic ACTH production. To our knowledge, it is the first reported case of ACTH secreting ovarian steroid cell tumor causing Cushing's syndrome.

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