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    J Bacteriol. 2002 Jun;184(12):3392-5.

    Formation of dTDP-rhamnose is essential for growth of mycobacteria.

    Ma Y, Pan F, McNeil M.

    Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA.

    It was determined that the dTDP-rhamnose synthesis gene, rmlD, could be inactivated in Mycobacterium smegmatis only in the presence of a rescue plasmid carrying functional rmlD. Hence, dTDP-rhamnose biosynthesis is essential for the growth of mycobacteria and the targeting of dTDP-rhamnose synthesis for new tuberculosis drugs is supported.

    PMID: 12029057 [PubMed - indexed for MEDLINE]

    PMCID: 135104

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