Formation of dTDP-rhamnose is essential for growth...[J Bacteriol. 2002]

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1: J Bacteriol. 2002 Jun;184(12):3392-5. Links

Formation of dTDP-rhamnose is essential for growth of mycobacteria.

Ma Y, Pan F, McNeil M.

Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA.

It was determined that the dTDP-rhamnose synthesis gene, rmlD, could be inactivated in Mycobacterium smegmatis only in the presence of a rescue plasmid carrying functional rmlD. Hence, dTDP-rhamnose biosynthesis is essential for the growth of mycobacteria and the targeting of dTDP-rhamnose synthesis for new tuberculosis drugs is supported.

PMID: 12029057 [PubMed - indexed for MEDLINE]

PMCID: PMC135104

Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose.
Antimicrob Agents Chemother. 2001 May; 45(5):1407-16.

[Antimicrob Agents Chemother. 2001]
Identification of a fourth gene involved in dTDP-rhamnose synthesis in Streptococcus mutans.
J Bacteriol. 1997 Jul; 179(13):4411-4.

[J Bacteriol. 1997]
Characterization of dTDP-4-dehydrorhamnose 3,5-epimerase and dTDP-4-dehydrorhamnose reductase, required for dTDP-L-rhamnose biosynthesis in Salmonella enterica serovar Typhimurium LT2.
J Biol Chem. 1999 Aug 27; 274(35):25069-77.

[J Biol Chem. 1999]
ReviewA structural perspective on the enzymes that convert dTDP-d-glucose into dTDP-l-rhamnose.
Biochem Soc Trans. 2003 Jun; 31(Pt 3):532-6.

[Biochem Soc Trans. 2003]
ReviewNutrient acquisition by mycobacteria.
Microbiology. 2008 Mar; 154(Pt 3):679-92.

[Microbiology. 2008]
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Cited by 3 PubMed Central articles

Expression, essentiality, and a microtiter plate assay for mycobacterial GlmU, the bifunctional glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase.
Zhang W, Jones VC, Scherman MS, Mahapatra S, Crick D, Bhamidi S, Xin Y, McNeil MR, Ma Y. Int J Biochem Cell Biol. 2008; 40(11):2560-71. Epub 2008 May 15.

[Int J Biochem Cell Biol. 2008]
Solid-phase synthesis of a thymidinyl dipeptide urea library.
Sun D, Lee RE. J Comb Chem. 2007 May-Jun; 9(3):370-85. Epub 2007 Apr 7.

[J Comb Chem. 2007]
RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation.
Dong C, Major LL, Srikannathasan V, Errey JC, Giraud MF, Lam JS, Graninger M, Messner P, McNeil MR, Field RA, et al. J Mol Biol. 2007 Jan 5; 365(1):146-59. Epub 2006 Sep 29.

[J Mol Biol. 2007]

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