Br J Haematol. 2002 Jun;117(3):763-4.

Three major glucose-6-phosphate dehydrogenase-deficient polymorphic variants identified in Mazandaran state of Iran.

Mesbah-Namin SA, Sanati MH, Mowjoodi A, Mason PJ, Vulliamy TJ, Noori-Daloii MR.

Source

Department of Biochemistry, School of Medical Sciences, Tarbiat Modarres University, PO Box 14115-331, Tehran, I.R. Iran. mesbahna@modares.ac.ir

Abstract

We report the first investigation of glucose- 6-phosphate dehydrogenase (G6PD) deficiency among the Mazandaranians in the north of Iran. We analysed the G6PD gene in 74 unrelated G6PD-deficient men with a history of favism. Molecular analysis revealed three major different polymorphic variants: G6PD Mediterranean 66.2% (49 out of 74), G6PD Chatham 27% (20 out of 74), G6PD Cosenza 6.75% (5 out of 74). These findings indicated a higher prevalence of G6PD Chatham in this Iranian population than anywhere else in the world. In addition, the distribution of these G6PD variants is more similar to that found in an Italian population than in other Middle Eastern countries.

PMID:: 12028056; [PubMed - indexed for MEDLINE]

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Glucosephosphate Dehydrogenase

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Cited by 3 PubMed Central articles

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Al-Allawi N, Eissa AA, Jubrael JM, Jamal SA, Hamamy H. BMC Blood Disord. 2010 Jul 5; 10:6. Epub 2010 Jul 5.
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The impact of phenotypic and genotypic G6PD deficiency on risk of plasmodium vivax infection: a case-control study amongst Afghan refugees in Pakistan.
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