Efficient ligandless palladium-catalyzed Suzuki reactions of potassium aryltrifluoroborates

Gary A Molander; Betina Biolatto

doi:10.1021/ol025845p

Efficient ligandless palladium-catalyzed Suzuki reactions of potassium aryltrifluoroborates

Org Lett. 2002 May 30;4(11):1867-70. doi: 10.1021/ol025845p.

Authors

Gary A Molander¹, Betina Biolatto

Affiliation

¹ Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USA. gmolander@sas.upenn.edu

PMID: 12027634
DOI: 10.1021/ol025845p

Abstract

[reaction: see text] The ligandless palladium-catalyzed Suzuki cross-coupling reaction of potassium aryl- and heteroaryltrifluoroborates with aryl- or heteroaryl halides or triflates proceeds readily with very good yields. The cross coupling can be effected in methanol or water, in the open air, using Pd(OAc)(2) as a catalyst in the presence of K(2)CO(3). A variety of functional groups are tolerated.