[Acanthamoeba keratitis, a possible dibromo propamidine isethionate resistance]

Arch Soc Esp Oftalmol. 2002 May;77(5):279-81.
[Article in Spanish]

Abstract

Purpose/method: To point out that acanthamoeba keratitis can show therapeutical resistance to dibrome propamidine isethionate (Brolene). We have a late diagnosis case of corneal melting on a bilateral acanthamoeba keratitis.

Results/conclusion: We performed corneal graft in one eye and found histopathological evidence of acanthamoeba. There was relapse in the graft in spite of Brolene treatment and good results when we changed to polyhidroxy methylbigunide (PHMB). In case of therapeutical Brolene resistance, PHMB can be an adequate alternative (Arch Soc Esp Oftalmol 2002; 77: 279-282).

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Acanthamoeba Keratitis / drug therapy*
  • Adult
  • Antiprotozoal Agents / therapeutic use*
  • Benzamidines / therapeutic use*
  • Drug Resistance
  • Humans
  • Male

Substances

  • Antiprotozoal Agents
  • Benzamidines
  • propamidine isethionate