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    GM-CSF regulation in eosinophils.

    Source

    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison 53792, USA.

    Abstract

    Allergic asthma is characterized by a temporally and quantitatively inappropriate immunologic response. One of the hallmarks of this response is the accumulation of eosinophils in the airway and lung parenchyma, which results in broncho-constriction, lung damage and, ultimately, fibrosis. Granulocyte-macrophage colony-stimulating factor (GM-CSF) plays a pivotal role in this process by modulating eosinophil function and survival. In this review, we discuss the effects and molecular regulation of GM-CSF secretion by eosinophils. Recent data demonstrate that activated eosinophils release small amounts of anti-apoptotic GM-CSF by stabilizing its coding mRNA.

    PMID:
    12022701
    [PubMed - indexed for MEDLINE]

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