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J Oral Maxillofac Surg. 2002 Jun;60(6):630-5.

Osteogenesis distraction and platelet-rich plasma for bone restoration of the severely atrophic mandible: preliminary results.

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  • 1Department of Maxillo-Facial Surgery, Faculty of Medicine, University of Udine, Udine, Italy.



The purpose of this study was to evaluate a new method of restoring severe atrophic mandible using platelet-rich plasma (PRP) during distraction osteogenesis.


Since 1999, 2 men and 3 women with severe atrophy (Cawood and Howell classes V and VI) of a completely edentulous mandible have been treated with a novel distraction procedure. During the surgery, a mixture of autologous bone graft, harvested from the iliac crest, and an autologous platelet concentrate, obtained from platelet-rich plasma, filled the distraction gap. This mixture constituted an autologous bone-platelet gel that was used to create a useful bony scaffold for distraction regenerate. After a latency period of 15 days, a distraction run of 0.5 mm/d, and a 60-day period of consolidation, the distraction device was removed and implants were placed simultaneously.


In all treated patients, planned distraction height was achieved with a considerable enhancement of bony regeneration, and in all cases it was possible to place implants at a planned time.


The combination of these recent and innovative regenerative methods seems to be effective in restoring the severe atrophic mandible.

Copyright 2002 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 60:630-635, 2002

[PubMed - indexed for MEDLINE]
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