BCG vaccination and GAD65 and IA-2 autoantibodies in autoimmune diabetes in southern India

C B Sanjeevi; Ashok K Das; A Shtauvere-Brameus

doi:10.1111/j.1749-6632.2002.tb02990.x

BCG vaccination and GAD65 and IA-2 autoantibodies in autoimmune diabetes in southern India

Ann N Y Acad Sci. 2002 Apr:958:293-6. doi: 10.1111/j.1749-6632.2002.tb02990.x.

Authors

C B Sanjeevi¹, Ashok K Das, A Shtauvere-Brameus

Affiliation

¹ Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden. sanjeevi.carani@molmed.ki.se

PMID: 12021127
DOI: 10.1111/j.1749-6632.2002.tb02990.x

Abstract

This paper reports a study to determine whether BCG vaccination is associated with an increase or decrease in GAD65 and I-A2 autoantibodies in cases of IDDM and NIDDM in southern India. It is concluded that BCG vaccination has an immunomodulatory role in these diseases.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Autoantibodies / immunology*
BCG Vaccine / adverse effects
BCG Vaccine / immunology*
Diabetes Mellitus, Type 1 / epidemiology
Diabetes Mellitus, Type 1 / immunology*
Glutamate Decarboxylase / immunology*
Humans
India / epidemiology
Isoenzymes / immunology*

Substances

Autoantibodies
BCG Vaccine
ICA512 autoantibody
Isoenzymes
Glutamate Decarboxylase
glutamate decarboxylase 2