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J Neuroimmunol. 2002 May;126(1-2):190-5.

Linear B-cell epitopes in Lambert-Eaton myasthenic syndrome defined by cell-free synthetic peptide binding.

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  • 1Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA.


Lambert-Eaton Myasthenic Syndrome (LEMS) is a rare autoimmune disorder characterized by autoantibodies that bind to P/Q voltage-gated calcium channels at the neuromuscular junction. Using cell-free direct peptide binding in 12 LEMS patients, we find linear B-cell epitopes that reside on the extracellular peptide linkers between the S5-S6 transmembrane peptides of Domains II and IV. A major epitope is located within the S5-S6 linker peptide of Domain IV defined by the acidic amino acid sequence EDEDSDEDE.

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