Abstract
Gallic acid (1) and methyl gallate (2) were isolated from Juca, a Brazilian folk medicine, fruits of Caesalpinia ferrea MART (Leguminosae), decreased significantly the average number of papillomas per mouse in the experiment of the promoting effects of 12-O-tetra- decanoylphorbol-13-acetate (TPA) on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene (DMBA).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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9,10-Dimethyl-1,2-benzanthracene / pharmacology
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Animals
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Anticarcinogenic Agents / chemistry
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Anticarcinogenic Agents / pharmacology*
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Brazil / ethnology
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Caesalpinia / chemistry*
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Female
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Fruit / chemistry
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Gallic Acid / analogs & derivatives*
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Gallic Acid / isolation & purification
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Gallic Acid / pharmacology
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Medicine, Traditional*
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Mice
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Mice, Inbred ICR
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Papilloma / chemically induced
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Papilloma / prevention & control
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Phytotherapy
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Skin Neoplasms / chemically induced*
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Skin Neoplasms / prevention & control*
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Tetradecanoylphorbol Acetate / pharmacology
Substances
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Anticarcinogenic Agents
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Plant Extracts
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9,10-Dimethyl-1,2-benzanthracene
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methyl gallate
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Gallic Acid
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Tetradecanoylphorbol Acetate