Reducing mortality in Salmonella enterica serovar Typhimurium-infected mice with a tripeptidic serum fraction

Todd A Parker; Kenneth O Willeford; Suzanne Parker; Karyl Buddington

doi:10.1128/AAC;46.6.1971-1973.2002

Reducing mortality in Salmonella enterica serovar Typhimurium-infected mice with a tripeptidic serum fraction

Antimicrob Agents Chemother. 2002 Jun;46(6):1971-3. doi: 10.1128/AAC;46.6.1971-1973.2002.

Authors

Todd A Parker¹, Kenneth O Willeford, Suzanne Parker, Karyl Buddington

Affiliation

¹ Department of Biochemistry and Molecular Biology, Mississippi State University, Mississippi State, Mississippi 39762, USA.

Abstract

Salmonellosis-induced mortality in female Swiss Webster mice decreased significantly when tripeptidic immunostimulant (TPI) was administered prophylactically. Prophylactic benefits developed in a dose-dependent manner wherein 15 mg of TPI given 1 day before challenge reduced mortality by 70%.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adjuvants, Immunologic / pharmacology*
Animals
Dose-Response Relationship, Drug
Female
Goats / physiology
Lipopolysaccharides / pharmacology
Macrophages / drug effects
Macrophages / microbiology
Mice
Oligopeptides / blood
Oligopeptides / pharmacology*
Salmonella Infections / drug therapy*
Salmonella Infections / mortality
Salmonella enterica*
Survival Analysis
Time Factors

Substances

Adjuvants, Immunologic
Lipopolysaccharides
Oligopeptides