Induction and suppression of RNA silencing by an animal virus.

Department of Plant Pathology and Center for Plant Cell Biology, University of California, Riverside, CA 92521, USA.

RNA silencing is a sequence-specific RNA degradation mechanism that is operational in plants and animals. Here, we show that flock house virus (FHV) is both an initiator and a target of RNA silencing in Drosophila host cells and that FHV infection requires suppression of RNA silencing by an FHV-encoded protein, B2. These findings establish RNA silencing as an adaptive antiviral defense in animal cells. B2 also inhibits RNA silencing in transgenic plants, providing evidence for a conserved RNA silencing pathway in the plant and animal kingdoms.

PMID: 12016316 [PubMed - indexed for MEDLINE]