Format

Send to

Choose Destination
See comment in PubMed Commons below
Science. 2002 May 17;296(5571):1316-9.

Heterotopic shift of epithelial-mesenchymal interactions in vertebrate jaw evolution.

Author information

  • 1Laboratory for Evolutionary Morphology, Center for Developmental Biology, RIKEN, Hyogo 650-0047, Japan.

Abstract

Genes involved in late specification of the mandibular arch, the source of the vertebrate jaw, are expressed with similar patterns in the oral regions of chick and lamprey embryos. However, morphological comparisons indicate that apparently orthologous homeobox genes were expressed in different subdivisions of the ectomesenchyme in the two species. Therefore, the homology and gene expression of the oral region are uncoupled during the transition from agnathan to gnathostome; we conclude that a heterotopic shift of tissue interaction was involved in the evolution of the jaw.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk