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Nuclear receptors. I. Nuclear receptors and bile acid homeostasis.

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  • 1Nuclear Receptor Discovery Research, GlaxoSmithKline, Five Moore Drive, Research Triangle Park, North Carolina 27709, USA.


Bile acids are required for the absorption of lipids and fat-soluble vitamins. The hepatic biosynthesis of bile acids is a major pathway for the catabolism and removal of cholesterol from the body. Because of their intrinsic toxicity, bile acid synthesis, transport, and metabolism must be tightly regulated. It is now apparent that members of the nuclear receptor family of lipid-activated transcription factors are key regulators of these physiological processes. A greater understanding of these receptors should afford novel opportunities for therapeutic intervention in chronic diseases such as cholestasis and dyslipidemia.

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