Efficacy of microfiltration in decreasing propofol-induced pain

Anaesthesia. 2002 Jun;57(6):557-61. doi: 10.1046/j.1365-2044.2002.02602.x.

Abstract

In a randomised, double-blinded, two-centre trial we evaluated the effect of a microbiological filter (Supor, Pall Life Sciences) on propofol injection pain. We studied 336 unpremedicated adult patients, who graded pain experienced during induction of anaesthesia with propofol on a 4-point verbal rating scale. Use of the microfilter reduced both the incidence and severity of propofol injection pain (p < 0.001). Incidence of severe pain in the filter group was 2.4% compared with 16.6% in the control group. Overall, 33.7% in the filter group experienced pain compared with 62.1% in the control group. A microbiological filter may provide a non-pharmacological alternative to a lidocaine/propofol mixture for reducing injection pain. It would also reduce the risk of any glass and bacterial contamination.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anesthetics, Intravenous / adverse effects*
  • Chi-Square Distribution
  • Double-Blind Method
  • Female
  • Glass
  • Humans
  • Injections, Intravenous
  • Irritants
  • Male
  • Micropore Filters*
  • Middle Aged
  • Pain / chemically induced
  • Pain / prevention & control*
  • Pain Measurement
  • Propofol / adverse effects*
  • Silicones

Substances

  • Anesthetics, Intravenous
  • Irritants
  • Silicones
  • Propofol