Spliceosomal snRNAs: Mg(2+)-dependent chemistry at the catalytic core?

Tommaso Villa; Jeffrey A Pleiss; Christine Guthrie

doi:10.1016/s0092-8674(02)00726-2

Spliceosomal snRNAs: Mg(2+)-dependent chemistry at the catalytic core?

Cell. 2002 Apr 19;109(2):149-52. doi: 10.1016/s0092-8674(02)00726-2.

Authors

Tommaso Villa¹, Jeffrey A Pleiss, Christine Guthrie

Affiliation

¹ Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA.

PMID: 12007401
DOI: 10.1016/s0092-8674(02)00726-2

Abstract

Since the discovery of self-splicing RNAs, it has been suspected that the snRNAs are the catalytic components of the spliceosome. Recent evidence supports both the catalytic potential of the spliceosomal snRNAs and their resemblance to elements of group II introns.

Publication types

Review

MeSH terms

Animals
Catalytic Domain / genetics*
Evolution, Molecular
Humans
Magnesium / metabolism*
Models, Biological
Molecular Structure
RNA Splicing / genetics*
RNA, Small Nuclear / genetics*
Spliceosomes / genetics*

Substances

RNA, Small Nuclear
Magnesium