Nature. 2002 May 23;417(6887):399-403. Epub 2002 May 8.

Comparative assessment of large-scale data sets of protein-protein interactions.

von Mering C, Krause R, Snel B, Cornell M, Oliver SG, Fields S, Bork P.

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European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany.

Abstract

Comprehensive protein protein interaction maps promise to reveal many aspects of the complex regulatory network underlying cellular function. Recently, large-scale approaches have predicted many new protein interactions in yeast. To measure their accuracy and potential as well as to identify biases, strengths and weaknesses, we compare the methods with each other and with a reference set of previously reported protein interactions.

PMID:: 12000970; [PubMed - indexed for MEDLINE]

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Comparative assessment of large-scale data sets of protein-protein interactions.

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