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    Am J Hum Genet. 1975 Nov;27(6):797-801.

    Linkage data on MN and the Hb beta locus.

    Barbosa CA, Koury WH, Krieger H.

    Abstract

    A sample of 28 informative families was studied for linkage between Hb beta and MN. Values of the neuterized recombination fraction from these and other families from the literature excluded a recombination fraction of less than .30 between these loci. Our results support different recombination values for males and females (theta equals .34 abd .50, respectively). A simple approach to estimate the sample size required as well as a study of the relationship between sibship size and sample size under conditions of loose linkage are also presented.

    PMID:
    1200031
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC1762910
    Free PMC Article

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