Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Apoptosis. 2002 Jun;7(3):247-60.

Molecular mechanisms of "detachment-induced apoptosis--Anoikis".

Author information

  • Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany.

Abstract

Apoptosis following loss of cell anchorage is of relevance for development, tissue homeostasis and disease. In the following the role of cell-matrix anchorage as well as cell-cell anchorage for cell survival and apoptosis is reviewed and the complex molecular mechanisms inducing and perpetuating detachment-induced apoptosis will be discussed with special emphasis on the role of caspases, p53, bcl-2 family members and the Fas signaling pathway.

PMID:
11997669
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk