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Ann Thorac Surg. 2002 Apr;73(4):1065-70.

Stage I non-small cell lung cancer: a pragmatic approach to prognosis after complete resection.

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  • 1Department of Thoracic Surgery and Lung Transplantation, Ste Marguerite Hospital, University Méditerranée (Aix-Marseille II), School of Medicine, France.



Long-term results of the surgical treatment of stage I non-small cell lung cancer (NSCLC) are disappointing.


Univariate and multivariate analyses were conducted on 515 consecutive lung resections for stage I NSCLC performed from 1990 to 1999 and identified by reviewing a database into which data were entered prospectively. Tumors were staged as stages IA (n = 147) and IB (n = 348) according to the 1997 UICC (Union Internationale Contre le Cancer) pTNM classification.


Operative mortality rates were 6.2%, 5.3%, 2.3%, and 0% for pneumonectomy, bilobectomy, lobectomy, and lesser resections, respectively. Overall survival rate was 61.1% (55.8% to 66.5%) at 5 years. Univariate analysis identified three significant adverse prognosticators: arteriosclerosis as comorbidity, pathologic T2 status, and blood vessel invasion. Male sex (p = 0.056) and performance of pneumonectomy (p = 0.057) were at the threshold of statistical significance. At multivariate analysis, three independent prognosticators entered the model: arteriosclerosis, blood vessels invasion, and performance of pneumonectomy.


Long-term survival of patients with completely resected stage I NSCLC was adversely influenced in a relatively balanced way by factors related to the clinical status of the patient, to the tumor, and to the treatment.

[PubMed - indexed for MEDLINE]
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