Recent unilateral decrease in visual acuity of a 72-year-old woman was the background of a comprehensive medical investigation that led to the definitive diagnosis of metastatic pancreatic carcinoma. Visual improvement was achieved after ocular irradiation but the patient died two months later because of bilateral pneumonia and sepsis. Ocular metastasis from advanced carcinoma of various organs is well known and usually is an indicative sign of poor prognosis. Ocular metastases from pancreatic carcinoma are extremely rare, and to the best of our knowledge, it has not been reported previously in English. It should be emphasized that unilateral decrease in visual acuity must be thoroughly investigated.