v-Src's hold over actin and cell adhesions. [Nat Rev Mol Cell Biol. 2002]

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1: Nat Rev Mol Cell Biol. 2002 Apr;3(4):233-45. Links

v-Src's hold over actin and cell adhesions.

Frame MC, Fincham VJ, Carragher NO, Wyke JA.

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK. mframe@beatson..gla.ac.uk

The oncoprotein v-Src and its cellular homologue (c-Src) are tyrosine kinases that modulate the actin cytoskeleton and cell adhesions. Through the concerted action of their protein-interaction and kinase domains, they are targeted to cell matrix integrin adhesions or cadherin-dependent junctions between epithelial cells, where they phosphorylate substrates that induce adhesion turnover and actin re-modelling. Recent experiments have defined some of the key targets and effector pathways that mediate the pleiotropic oncogenic effects of v-Src.

PMID: 11994743 [PubMed - indexed for MEDLINE]

The SH3 domain directs acto-myosin-dependent targeting of v-Src to focal adhesions via phosphatidylinositol 3-kinase.
Mol Cell Biol. 2000 Sep; 20(17):6518-36.

[Mol Cell Biol. 2000]
v-Src rescues actin-based cytoskeletal architecture and cell motility and induces enhanced anchorage independence during oncogenic transformation of focal adhesion kinase-null fibroblasts.
J Biol Chem. 2003 Nov 28; 278(48):47946-59. Epub 2003 Sep 18.

[J Biol Chem. 2003]
SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signaling.
Mol Cell Biol. 2004 Sep; 24(18):8113-33.

[Mol Cell Biol. 2004]
ReviewNewest findings on the oldest oncogene; how activated src does it.
J Cell Sci. 2004 Mar 1; 117(Pt 7):989-98.

[J Cell Sci. 2004]
ReviewFunction, location, and regulation of the src protein-tyrosine kinase.
Princess Takamatsu Symp. 1989; 20:63-70.

[Princess Takamatsu Symp. 1989]
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Hayes MJ, Moss SE. J Biol Chem. 2009 Apr 10; 284(15):10202-10. Epub 2009 Feb 4.

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Building epithelial tissues from skin stem cells.
Fuchs E, Nowak JA. Cold Spring Harb Symp Quant Biol. 2008; 73:333-50. Epub 2008 Nov 6.

[Cold Spring Harb Symp Quant Biol. 2008]
The cellular prion protein PrP(c) is involved in the proliferation of epithelial cells and in the distribution of junction-associated proteins.
Morel E, Fouquet S, Strup-Perrot C, Pichol Thievend C, Petit C, Loew D, Faussat AM, Yvernault L, Pinçon-Raymond M, Chambaz J, et al. PLoS One. 2008 Aug 20; 3(8):e3000. Epub 2008 Aug 20.

[PLoS One. 2008]
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