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    Nat Rev Mol Cell Biol. 2002 Apr;3(4):233-45.

    v-Src's hold over actin and cell adhesions.

    Frame MC, Fincham VJ, Carragher NO, Wyke JA.

    The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK. mframe@beatson..gla.ac.uk

    The oncoprotein v-Src and its cellular homologue (c-Src) are tyrosine kinases that modulate the actin cytoskeleton and cell adhesions. Through the concerted action of their protein-interaction and kinase domains, they are targeted to cell matrix integrin adhesions or cadherin-dependent junctions between epithelial cells, where they phosphorylate substrates that induce adhesion turnover and actin re-modelling. Recent experiments have defined some of the key targets and effector pathways that mediate the pleiotropic oncogenic effects of v-Src.

    PMID: 11994743 [PubMed - indexed for MEDLINE]

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