Drug Resist Updat. 2001 Oct;4(5):322-9.

Are cytochrome b gene mutations the only cause of atovaquone resistance in Pneumocystis?

Source

Department of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221, USA. Edna.Kaneshiro@uc.edu

Abstract

There is evidence that exposure of the opportunistic pathogen Pneumocystis to atovaquone enhances the development of resistance to the drug. Atovaquone is a structural analog of ubiquinone, which binds to the mitochondrial cytochrome bc(1) complex and inhibits electron transport. Like the parasites Plasmodium and Toxoplasma, atovaquone resistance can result from mutations in the cytochrome b gene of Pneumocystis. However, atovaquone resistance cannot be explained by cytochrome b gene mutations in all cases. The discovery that atovaquone also inhibits biosynthesis of ubiquinone in P. carinii may unfold other mechanisms by which drug resistance develops.

PMID:: 11991686; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Pneumocystis Infections - MedlinePlus Health Information

Molecular Biology Databases

ATOVAQUONE - HSDB

Supplemental Content

Save items

Related citations in PubMed

Recapitulation in Saccharomyces cerevisiae of cytochrome b mutations conferring resistance to atovaquone in Pneumocystis jiroveci. [Antimicrob Agents Chemother. 2...]
Recapitulation in Saccharomyces cerevisiae of cytochrome b mutations conferring resistance to atovaquone in Pneumocystis jiroveci.
Hill P, Kessl J, Fisher N, Meshnick S, Trumpower BL, Meunier B. Antimicrob Agents Chemother. 2003 Sep; 47(9):2725-31.
Sequence polymorphisms in the Pneumocystis carinii cytochrome b gene and their association with atovaquone prophylaxis failure. [J Infect Dis. 1998]
Sequence polymorphisms in the Pneumocystis carinii cytochrome b gene and their association with atovaquone prophylaxis failure.
Walker DJ, Wakefield AE, Dohn MN, Miller RF, Baughman RP, Hossler PA, Bartlett MS, Smith JW, Kazanjian P, Meshnick SR. J Infect Dis. 1998 Dec; 178(6):1767-75.
Effects of atovaquone and diospyrin-based drugs on the cellular ATP of Pneumocystis carinii f. sp. carinii. [Antimicrob Agents Chemother. 2...]
Effects of atovaquone and diospyrin-based drugs on the cellular ATP of Pneumocystis carinii f. sp. carinii.
Cushion MT, Collins M, Hazra B, Kaneshiro ES. Antimicrob Agents Chemother. 2000 Mar; 44(3):713-9.
Review Antiparasitic agent atovaquone. [Antimicrob Agents Chemother. 2...]
Review Antiparasitic agent atovaquone.
Baggish AL, Hill DR. Antimicrob Agents Chemother. 2002 May; 46(5):1163-73.
Review A need for standardized definitions for clinical studies of Pneumocystis. [J Eukaryot Microbiol. 2006]
Review A need for standardized definitions for clinical studies of Pneumocystis.
Miller RF, Huang L. J Eukaryot Microbiol. 2006; 53 Suppl 1:S87-8.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Are cytochrome b gene mutations the only cause of atovaquone resistance in Pneum...
Are cytochrome b gene mutations the only cause of atovaquone resistance in Pneumocystis?
Drug Resist Updat. 2001 Oct ;4(5):322-9.

PubMed
If not apoptosis, then what? Treatment-induced senescence and mitotic catastroph...
If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells.
Drug Resist Updat. 2001 Oct ;4(5):303-13.

PubMed
Transcript abundance supercedes editing efficiency as a factor in developmental ...
Transcript abundance supercedes editing efficiency as a factor in developmental variation of chloroplast gene expression.
RNA. 2002 Apr ;8(4):497-511.

PubMed
Marginalization among the marginalized: gay men's anti-effeminacy attitudes.
Marginalization among the marginalized: gay men's anti-effeminacy attitudes.
J Homosex. 2001 ;42(1):1-28.

PubMed
Treatment of varicose and telangiectatic leg veins: double-blind prospective com...
Treatment of varicose and telangiectatic leg veins: double-blind prospective comparative trial between aethoxyskerol and sotradecol.
Dermatol Surg. 2002 Jan ;28(1):52-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Are cytochrome b gene mutations the only cause of atovaquone resistance in Pneumocystis?

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information