Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cell Mol Biol (Noisy-le-grand). 2002 Mar;48(2):213-7.

The HERV-W/7q family in the human genome. Potential for protein expression and gene regulation.

Author information

  • 1INSERM U-488, Bâtiment Gregory Pincus, Le Kremlin-Bicêtre, France. alliel@kb.inserm.fr

Abstract

A new family of human endogenous retroviruses has recently been discovered. The best known example of a full length member of this family, HERV-W/7q, is located on chromosome 7. HERV-W/7q is characterized by a long open reading frame within its env gene which is expressed in various tissues, and mainly in placenta, as a protein that we called enverin. A search for new retroviral sequences related to the HERV-W/7q family allowed the characterization of such elements in chromosome 6. A novel full length HERV with an env gene of the HERV-W/7q type, potentially encoding a truncated form of enverin has been identified on chromosome 10. The distribution of HERV-W/7q related sequences close to or within genes offers the possibility that the expression of these genes may be regulated by their companion retroviral sequences.

PMID:
11990458
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk