Nat Rev Genet. 2002 May;3(5):397-403.

Timeline: Neurospora: a model of model microbes.

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Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697-3900, USA. rhdavis@uci.edu

Abstract

In the 1940s, studies with Neurospora pioneered the use of microorganisms in genetic analysis and provided the foundations for biochemical genetics and molecular biology. What has happened since this orange mould was used to show that genes control metabolic reactions? How did it come to be the fungal counterpart of Drosophila? We describe its continued use during the heyday of research with Escherichia coli and yeast, and its emergence as a biological model for higher fungi.

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