Nat Rev Genet. 2002 May;3(5):370-9.

Alu repeats and human genomic diversity.

Source

Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, Louisiana 70803, USA. mbatzer@lsu.edu

Abstract

During the past 65 million years, Alu elements have propagated to more than one million copies in primate genomes, which has resulted in the generation of a series of Alu subfamilies of different ages. Alu elements affect the genome in several ways, causing insertion mutations, recombination between elements, gene conversion and alterations in gene expression. Alu-insertion polymorphisms are a boon for the study of human population genetics and primate comparative genomics because they are neutral genetic markers of identical descent with known ancestral states.

PMID:: 11988762; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Retroelements

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Recently integrated Alu elements and human genomic diversity. [Mol Biol Evol. 2003]
Recently integrated Alu elements and human genomic diversity.
Salem AH, Kilroy GE, Watkins WS, Jorde LB, Batzer MA. Mol Biol Evol. 2003 Aug; 20(8):1349-61. Epub 2003 May 30.
Comprehensive analysis of two Alu Yd subfamilies. [J Mol Evol. 2003]
Comprehensive analysis of two Alu Yd subfamilies.
Xing J, Salem AH, Hedges DJ, Kilroy GE, Watkins WS, Schienman JE, Stewart CB, Jurka J, Jorde LB, Batzer MA. J Mol Evol. 2003; 57 Suppl 1:S76-89.
Large-scale analysis of the Alu Ya5 and Yb8 subfamilies and their contribution to human genomic diversity. [J Mol Biol. 2001]
Large-scale analysis of the Alu Ya5 and Yb8 subfamilies and their contribution to human genomic diversity.
Carroll ML, Roy-Engel AM, Nguyen SV, Salem AH, Vogel E, Vincent B, Myers J, Ahmad Z, Nguyen L, Sammarco M, et al. J Mol Biol. 2001 Aug 3; 311(1):17-40.
Review Alu repeats and human disease. [Mol Genet Metab. 1999]
Review Alu repeats and human disease.
Deininger PL, Batzer MA. Mol Genet Metab. 1999 Jul; 67(3):183-93.
Review [Alu family and its biological significance]. [Yi Chuan. 2005]
Review [Alu family and its biological significance].
Luo DX, Li K, He SY, Liao DF. Yi Chuan. 2005 Mar; 27(2):284-8.

See reviews... See all...

Cited by over 100 PubMed Central articles

A gene expression restriction network mediated by sense and antisense Alu sequences located on protein-coding messenger RNAs. [BMC Genomics. 2013]
A gene expression restriction network mediated by sense and antisense Alu sequences located on protein-coding messenger RNAs.
Liang KH, Yeh CT. BMC Genomics. 2013 May 11; 14:325. Epub 2013 May 11.
Intrinsic immunity against retrotransposons by APOBEC cytidine deaminases. [Front Microbiol. 2013]
Intrinsic immunity against retrotransposons by APOBEC cytidine deaminases.
Koito A, Ikeda T. Front Microbiol. 2013; 4:28. Epub 2013 Feb 20.
New clinical and molecular insights on Barth syndrome. [Orphanet J Rare Dis. 2013]
New clinical and molecular insights on Barth syndrome.
Ferri L, Donati MA, Funghini S, Malvagia S, Catarzi S, Lugli L, Ragni L, Bertini E, Vaz FM, Cooper DN, et al. Orphanet J Rare Dis. 2013 Feb 14; 8(1):27. Epub 2013 Feb 14.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Alu repeats and human genomic diversity.
Alu repeats and human genomic diversity.
Nat Rev Genet. 2002 May ;3(5):370-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: