Nat Cell Biol. 2002 May;4(5):E131-6.

AP-1 as a regulator of cell life and death.

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Department of Experimental Medicine and Cancer Research, School of Medicine, the Hebrew University, Jerusalem, 91120, Israel. eshaulian@md.huji.ac.il

Abstract

The transcription factor AP-1 (activator protein-1) is involved in cellular proliferation, transformation and death. Using mice and cells lacking AP-1 components, the target-genes and molecular mechanisms mediating these processes were recently identified. Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour suppressors, as well as upregulation of positive cell cycle regulators. Mostly, c-Jun is a positive regulator of cell proliferation, whereas JunB has the converse effect. The intricate relationships between the different Jun proteins, their activities and the mechanisms that mediate them will be discussed.

PMID:: 11988758; [PubMed - indexed for MEDLINE]

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