Nat Cell Biol. 2002 May;4(5):E113-6.

Taking a bite: proteasomal protein processing.

Source

Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, 82152 Martinsried, Germany.

Abstract

The proteasome is a hollow cylindrical protease that contains active sites concealed within its central cavity. Proteasomes usually completely degrade substrates into small peptides, but in a few cases, degradation can yield biologically active protein fragments. Examples of this are the transcription factors NF-kappa B, Spt23p and Mga2p, which are generated from precursors by proteasomal processing. How distinct protein domains are spared from degradation remains a matter of debate. Here, we discuss several models and suggest a novel mechanism for proteasomal processing.

PMID:: 11988749; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing. [Cell. 2000]
Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing.
Hoppe T, Matuschewski K, Rape M, Schlenker S, Ulrich HD, Jentsch S. Cell. 2000 Sep 1; 102(5):577-86.
Proteasome-mediated protein processing by bidirectional degradation initiated from an internal site. [Nat Struct Mol Biol. 2006]
Proteasome-mediated protein processing by bidirectional degradation initiated from an internal site.
Piwko W, Jentsch S. Nat Struct Mol Biol. 2006 Aug; 13(8):691-7. Epub 2006 Jul 16.
Proteasomal degradation of RPN4 via two distinct mechanisms, ubiquitin-dependent and -independent. [J Biol Chem. 2004]
Proteasomal degradation of RPN4 via two distinct mechanisms, ubiquitin-dependent and -independent.
Ju D, Xie Y. J Biol Chem. 2004 Jun 4; 279(23):23851-4. Epub 2004 Apr 16.
Review [The proteasome: destroy to live]. [Mol Biol (Mosk). 2002]
Review [The proteasome: destroy to live].
Abramova EB, Sharova NP, Karpov VL. Mol Biol (Mosk). 2002 Sep-Oct; 36(5):761-76.
Review The ubiquitin-proteasome pathway. [Ann Med. 2004]
Review The ubiquitin-proteasome pathway.
Roos-Mattjus P, Sistonen L. Ann Med. 2004; 36(4):285-95.

See reviews... See all...

Cited by 13 PubMed Central articles

Direct ubiquitin independent recognition and degradation of a folded protein by the eukaryotic proteasomes-origin of intrinsic degradation signals. [PLoS One. 2012]
Direct ubiquitin independent recognition and degradation of a folded protein by the eukaryotic proteasomes-origin of intrinsic degradation signals.
Singh Gautam AK, Balakrishnan S, Venkatraman P. PLoS One. 2012; 7(4):e34864. Epub 2012 Apr 10.
A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome. [J Biol Chem. 2011]
A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome.
Schrader EK, Harstad KG, Holmgren RA, Matouschek A. J Biol Chem. 2011 Nov 11; 286(45):39051-8. Epub 2011 Sep 15.
Proteasomal degradation from internal sites favors partial proteolysis via remote domain stabilization. [ACS Chem Biol. 2011]
Proteasomal degradation from internal sites favors partial proteolysis via remote domain stabilization.
Kraut DA, Matouschek A. ACS Chem Biol. 2011 Oct 21; 6(10):1087-95. Epub 2011 Aug 12.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Taking a bite: proteasomal protein processing.
Taking a bite: proteasomal protein processing.
Nat Cell Biol. 2002 May ;4(5):E113-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: