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1: Mol Cell Endocrinol. 2002 Feb 22;187(1-2):107-11.Click here to read Links

Spermatogonial stem cell preservation and transplantation.

Schlatt S.

Center for Animal Transgenesis and Germ Cell Research, University of Pennsylvania, 382 West Street Rd, Kennett Square, PA 19348, USA. schlatt@vet.upenn.edu

Spermatogonia are the male germ line stem cells. Their life long expansion is needed for permanent production of male germ cells. Spermatogonia are the only cells of the germ line, which proliferate in adulthood and offer interesting applications as they are potentially totipotent and immortal cells. This review presents some of the recent breakthroughs, which have led to a better understanding of spermatogonial physiology and opened new fields of basic research and of clinical applications in veterinary and medical science.

PMID: 11988317 [PubMed - indexed for MEDLINE]