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Biochem J. 2002 May 15;364(Pt 1):101-4.

L-Lactate transport into rat heart mitochondria and reconstruction of the L-lactate/pyruvate shuttle.

Author information

  • 1Centro di Studio sui Mitocondri e Metabolismo Energetico, CNR, Via Amendola 165/A, 70126, Bari, Italy.

Abstract

In vitro reconstruction of the L-lactate/pyruvate shuttle has been performed, which allows NADH oxidation outside rat heart mitochondria. Such a shuttle occurs due to the combined action of the novel mitochondrial L-lactate/pyruvate antiporter, which differs from the monocarboxylate carrier, and the mitochondrial L-lactate dehydrogenase. The rate of L-lactate/pyruvate antiport proved to regulate the shuttle in vitro.

PMID:
11988081
[PubMed - indexed for MEDLINE]
PMCID:
PMC1222550
Free PMC Article
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