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Prostate. 2002 Jun 1;51(4):276-85.

Worry and attitude of men in at-risk families for prostate cancer about genetic susceptibility and genetic testing.

Author information

  • 1Department of Urology, CHU Nancy-Brabois, Vandoeuvre-les-Nancy, France. l.cormier@chu-nancy.fr

Abstract

BACKGROUND:

The aim of this study was to evaluate worry about genetic susceptibility and the attitude of men with family history of prostate cancer (CaP) toward genetic testing.

METHODS:

Three hundred seventy-five eligible first-degree relatives (FDR) of men with CaP, were asked to participate in a screening and to fill out a survey covering the worry about genetic susceptibility and interest in genetic testing.

RESULTS:

Of the 375 candidates contacted, 277 completed the survey, and had undergone PSA measurement. Sixty-four percent worried a little or not at all about inherited predisposition to CaP, while the remainder worried a lot or extremely. The candidates who worried a lot or extremely were men with high levels of durable anxiety disposition (STAI trait), who had undergone a previous screening procedure and men with sons. Ninety-eight percent of men expressed their interest in undergoing genetic testing. The most motivated candidates to have the test done were men with several relatives with CaP.

CONCLUSIONS:

The level of worry about genetic susceptibility was low and there was a concrete interest in genetic testing in FDR of men with CaP. This interest increased with the number of CaP in the family.

Copyright 2002 Wiley-Liss, Inc.

PMID:
11987156
[PubMed - indexed for MEDLINE]
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