Jpn J Cancer Res. 2002 Apr;93(4):397-403.

Expansion of lung V alpha 14 NKT cells by administration of alpha-galactosylceramide-pulsed dendritic cells.

Akutsu Y, Nakayama T, Harada M, Kawano T, Motohashi S, Shimizu E, Ito T, Kamada N, Saito T, Matsubara H, Miyazawa Y, Ochiai T, Taniguchi M.

Source

CREST (Core Research for Evolutional Science and Technology) Project, JST, Kawaguchi, Saitama 332-0012, Japan.

Abstract

NKT cells, a novel murine lymphoid lineage bearing an invariant T cell receptor encoded by V alpha 14 and J alpha 281 gene segments, recognize a specific ligand glycolipid, alpha-galactosylceramide (alpha-GalCer) in a CD1d-dependent manner. Recent research has revealed that activated V alpha 14 NKT cells have dramatic antitumor effects against a wide variety of tumor cell lines in vivo and in vitro. Here, we demonstrate strong in vivo antitumor effects brought about by treatment with alpha-GalCer-pulsed dendritic cells in comparison with in vitro-activated V alpha 14 NKT cells. Furthermore, we show a significant expansion of endogenous V alpha 14 NKT cells in the lung following the administration of alpha-GalCer-pulsed dendritic cells. The feasibility of immunotherapy with alpha-GalCer-pulsed dendritic cells is discussed.

PMID:: 11985789; [PubMed - indexed for MEDLINE]

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