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Cell. 2002 Apr;109 Suppl:S81-96.

Missing pieces in the NF-kappaB puzzle.

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  • 1Section of Immunobiology, Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. sankar.ghosh@yale.edu

Abstract

The regulation of the transcription factor NF-kappaB activity occurs at several levels including controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A critical component in NF-kappaB regulation is the IkappaB kinase (IKK) complex. This review is focused on recent progress as well as unanswered questions regarding the regulation and function of NF-kappaB and IKK.

PMID:
11983155
[PubMed - indexed for MEDLINE]
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