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    Cell. 2002 Apr;109 Suppl:S21-33.

    Genetic control of MHC class II expression.

    Ting JP, Trowsdale J.

    Source

    Department of Microbiology and Immunology and The Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA. panyun@med.unc.edu

    Abstract

    The presentation of peptides to T cells by MHC class II molecules is of critical importance in specific recognition by the immune system. Expression of class II molecules is exquisitely controlled at the transcriptional level. A large set of proteins interact with the promoters of class II genes. The most important of these is CIITA, a master controller that orchestrates expression but does not bind directly to the promoter. The transcriptosome complex formed at class II promoters is a model for induction of gene expression.

    PMID:
    11983150
    [PubMed - indexed for MEDLINE]

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