Science. 1975 Nov 21;190(4216):787-9.

Hepatic peroxisome proliferation: induction by two novel compounds structurally unrelated to clofibrate.

Abstract

Two hypolipidemic compounds [ 4-chloro-6(2,3-xylidino)-2-pyrimidinyl-thio] acetic acid, and 2-chloro-5(3,5-dimethylpiperidinosufony)benzoic acid (tibric acid) greatly increased the number of peroxisomes (microbodies) in liver cells of rats and mice. This augmented peroxisome population was accompanied by significant elevation of liver catalase activity. These two hypolipidemic peroxisome proliferators are structurally different from ethyl a-p-chlorophenozyisobutyrate (clofibrate) and other hypolipidemic, arylocyisobutyrate derivatives which cause hepatic peroxisome proliferation. Induction of peroxisome proliferation by these structurally unrelated hypolipidemic compounds suggests a possible relation between hepatic peroxisome proliferation and hypolipidemia.

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Evaluation of selected hypolipidemic agents for the induction of peroxisomal enzymes and peroxisome proliferation in the rat liver. [Hum Toxicol. 1983]
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Lalwani ND, Reddy MK, Qureshi SA, Sirtori CR, Abiko Y, Reddy JK. Hum Toxicol. 1983 Jan; 2(1):27-48.
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Reddy JK, Lalwai ND. Crit Rev Toxicol. 1983; 12(1):1-58.

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