Dev Cell. 2002 Apr;2(4):381-2.

Chromosome segregation: playing polo in prophase.

Source

Chromosome Segregation Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, WC2A 3PX, London, United Kingdom.

Abstract

During mitosis, in most eukaryotes, cohesin is removed from chromosomes in two steps. A paper in the March issue of Molecular Cell identifies Polo-like kinase as a key regulator for the first step that releases much of cohesin during prophase.

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Science. 2000 May 26;288(5470):1379-85.

PMID:: 11970886; [PubMed - indexed for MEDLINE]

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