Send to

Choose Destination
See comment in PubMed Commons below
Drug Discov Today. 2002 Apr 15;7(8):479-85.

Targeting tumors with non-viral gene delivery systems.

Author information

  • 1Department of Pharmacy, Ludwig-Maximilians-Universit√§t, M√ľnchen, Butenandtstrasse 5-13, D-81377 Munich, Germany.


Targeting therapeutic genes to tumors is an attractive concept in curing malignant diseases. Systemic gene delivery systems are needed for therapeutic applications in which the target cells are not directly accessible, and which can only be reached via the systemic route. Recent developments in the field of non-viral gene delivery have shown that, based on (poly)cationic carrier molecules, DNA can be efficiently targeted to tumors via the bloodstream. Tailor-made synthetic vectors can be used to achieve predominant gene expression in tumor tissue. Therapeutic concepts based, for example, on suicide genes or cytokines, showed encouraging results in preclinical and also in first clinical evaluations.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk