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Curr Opin Allergy Clin Immunol. 2001 Oct;1(5):455-60.

The role of lymphocytes in healthy and eczematous skin.

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  • 1Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan. tamaki-der@h.u-tokyo.ac.jp


Eczema is a heterogeneous disease and the pathophysiological mechanism should be clarified in each disease. Allergic contact dermatitis and atopic dermatitis are representative diseases showing eczematous reaction. A major player in both allergic contact dermatitis and atopic dermatitis is skin-specific T lymphocytes. The significance of these T lymphocytes, especially the expression of cutaneous lymphocyte-associated antigen on T helper cells types 1 and 2, and its counter-receptor on vascular endothelial cells needs further investigation. The evidence showing that infiltrating T cells participate in the formation of eczematous reaction through Fas-induced apoptosis is important in our understanding of eczematous reactions and also for treatment.

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