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Cell. 2002 Apr 5;109(1):5-8.

Antigenic variation and allelic exclusion.

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  • The Netherlands Cancer Institute, Division of Molecular Biology and Center for Biomedical Genetics, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. p.borst@nki.nl


Cells often express only one gene from a set of two or more. African trypanosomes appear to accomplish this monoallelic expression by segregating the selected gene into a specific nuclear body. The possibility that such a structure might explain monoallelic expression in other multigene systems is discussed here.

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